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- ****************************************************
- * Ribonucleotide reductase large subunit signature *
- ****************************************************
-
- Ribonucleotide reductase (EC 1.17.4.1) [1,2] catalyzes the reductive synthesis
- of deoxyribonucleotides from their corresponding ribonucleotides. It provides
- the precursors necessary for DNA synthesis. Ribonucleotide reductase is an
- oligomeric enzyme composed of a large subunit (700 to 1000 residues) and a
- small subunit (300 to 400 residues). There are regions of similarities in the
- sequence of the large chain from prokaryotes, eukaryotes and viruses. We have
- selected one of these regions as a signature pattern.
-
- -Consensus pattern: G-x(2)-N-[GS]-x(3)-A-x-M-P
- -Sequences known to belong to this class detected by the pattern: ALL.
- -Other sequence(s) detected in SWISS-PROT: Escherichia coli catalase hpi.
- -Last update: October 1993 / Text revised.
-
- [ 1] Nillson O., Lundqvist T., Hahne S., Sjoberg B.-M.
- Biochem. Soc. Trans. 16:91-94(1988).
- [ 2] Reichard P.
- Science 260:1773-1777(1993).
-